Stress: one of the cause for Diabetes that further leads to Osteoporosis

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AUTHOR

Hitesh Kaushik1*, Mahak Saxena1, Devanshi Gautam1, Kajal Kumari1, Prince1, Avinash Kumar1

ABSTRACT  

Stress is characterised as a condition of anxiety or mental tension brought on by a challenging circumstance. Stress is a typical human response that drives us to confront challenges and threats in our lives. Everyone goes through periods of stress. Stress causes the body to release hormones that may raise blood sugar levels. Diabetes patients may experience negative symptoms from this, although they may be controlled. People who have Type 1 diabetes, in which the pancreas stops producing insulin, or Type 2 diabetes, in which the body cannot utilise insulin and the ability to generate insulin gradually declines, are more likely to experience bone fractures and osteoporosis. Women with Type 1 diabetes are 12 times more likely to fracture than women without diabetes, which is linked to lower bone mass. Osteoporosis Because it typically goes undiagnosed until a bone is shattered, and sometimes even then, osteoporosis is referred described as a “silent” illness.

 Keywords: Stress, Osteoblastogenesis, Mental illness, Diabetes

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Kaushik et al.. Int. J. Sci. Info. 2023, 1 (2)

Excess intake of Glucocorticoids leading to Osteoporosis

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AUTHOR

Hitesh Kaushik1*, Mahak Saxena1

ABSTRACT  

Glucocorticoids are potent medications that reduce inflammation and boost your immune system to treat a variety of illnesses. Basal GC levels are crucial for intermediate metabolism and play a role in the growth and homeostasis of a variety of bodily tissues, including the skeleton, from a physiological standpoint. Numerous investigations on mammals have shown that GC hormones play a beneficial effect in bone remodelling and modelling by promoting osteoblastogenesis, which preserves the bone architecture. Although the so-called stress hormones’ pharmaceutical effects have received considerable attention, little is known about the impact of endogenous GCs on bone mineral metabolism as a result of the endocrine stress response in vertebrates. Additionally, stress reactions differ among vertebrate lineages and depend on the stressor (such as mineral requirements, physical stress, and psychological stress), life cycle events (such as migration and ageing), and stressor (such as starvation, predation, and environmental change). This review aims to provide an overview of how endogenous GCs affect bone metabolism. Osteoporosis is a medical disorder that causes bones to become brittle and more prone to breaking. Stress, which causes physical, emotional, and intellectual reactions, is a typical bodily response to change.

 Keywords: Glucocorticoids, Stress, Osteoblastogenesis, Osteoporosis

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Kaushik and Saxena. Int. J. Sci. Info. 2023, 1 (2)

Social Anxiety Leading to Osteoporosis

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AUTHOR

Hitesh Kaushik1*, Mahak Saxena1

ABSTRACT  

An anxiety disorder that is frequently seen is social anxiety disorder. Speaking in front of a group, dating, interacting with a cashier at a store, taking part in a job interview, meeting new people, etc. are examples of circumstances where persons with social anxiety disorder experience symptoms of worry or panic. Women with significant levels of pre-existing health anxiety scored more anxious about osteoporosis and anticipated chance of acquiring osteoporosis. When bone mass, bone mineral density, or the composition and strength of bone alter, osteoporosis, a disease of the bones, results. This could lead to a decrease in bone density and a higher risk of fractures (broken bones).

 Keywords: Anxiety, Osteoporosis, Social anxiety

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Kaushik and Saxena. Int. J. Sci. Info. 2023, 1 (2)

Replacement of Fishmeal with plant origin Soybean Protein for Sustainable Aquaculture: A Review Article

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AUTHOR

Anupam Sehra1, Meenakshi Jindal2*, Jyoti, M3 and Nirmala Rathee1

ABSTRACT

To get nutritionally rich fish flesh, a nutritionally balanced diet is necessary. The use of rice bran and oil cakes alone does not contain enough nutrients for the better growth of fish. Fishmeal (FM) is major protein source in aqua feeds, but not affordable due to its high price. Therefore, many plant proteins like Soybean, canola, guar etc. are recommended by many nutritionists due to their low price. But among all these plant protein ingredients, soybean is considered as the good nutritive and affordable ingredient in fish feed. The literature under this review revealed how anti nutritional factors present in soybean interfere with the growth of fish and how they can be removed after processing. This review also revealed how the use of processed soybean results in good growth of fish.

 Keywords: Anti-nutritional factors, fish, growth, soybean

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Sehra. Int. J. Sci. Info. 2023, 1 (2)

Dental 4d-printing

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AUTHOR

Khushboo Bhaker*

ABSTRACT  

The studies of interior 4D printing in dentistry will be increasing to supply smart bridges, complex dental crowns, aligners, surgical templates, and orthodontic braces adjusted consistent with the requirement of the person affected man or woman after temperature trade. It brings a cutting-edge revolution in dentistry. 4D printing can create dental implants with houses as specific as herbal teeth. 4D printed dental implants have personal tendencies of dimensional modifications that might assist to keep away from marginal leakage. smart orthodontics implants enhance the function of ligatures and wires that assist teeth to transport inside the desired direction. the one’s implants can adjust the state of affairs with no need for human management. In Destiny, 4D printing can print low-value, smart, functional dentures using a couple of biocompatible substances. it can offer a great solution for producing numerous styles of clever, customized dentistry versions which can develop as an affected character’s enamel increases. Now, 4D printing can resolve various issues which are the difficulty of 3-d printing technology. This period can develop as unexpectedly as virtual dentistry.

 Keywords: Dental, 4D printing, Dentistry, Dental crowns, Dental implants

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Bhaker, Int. J. Sci. Info. 2023, 1 (2)

The Coevolution of Virophages and Their Hosts: A Comprehensive Review

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AUTHOR

Vibhor*, Amanjeet, Md. Murad Hossain

ABSTRACT  

Virophages are small, satellite viruses that depend on the replication machinery of their host viruses. While originally thought to be rare and unique to certain environments, the discovery of numerous virophages has led to an increased understanding of their importance in regulating viral dynamics and their potential impact on ecosystems. This paper provides a comprehensive review of the coevolutionary relationship between virophages and their hosts. We examine the evolutionary history of virophages, their role in modulating viral communities, and the mechanisms underlying their interactions with host viruses. Additionally, we discuss the potential implications of virophages for human health and biotechnology. Through an analysis of current research, we highlight the gaps in knowledge and identify promising avenues for future studies.

 Keywords: Virophages, Coevolutionary, Viruses

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Vibhor, Int. J. Sci. Info. 2023, 1 (2)

Deep Eutectic Solvents: An Overview Of Its Basics And Properties

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AUTHOR

Khushboo Bhaker*

ABSTRACT  

Deep eutectic solvents (DESs) are a rising elegance of combos characterized by using sizeable depressions in melting factors as compared to the ones of the neat constituent additives. These substances are promising for programs as cheaper “designer” solvents showing a bunch of tunable physicochemical properties. An in-depth review of the modern-day literature reveals the lack of predictive knowledge of the microscopic mechanisms that govern the shape–property relationships in this elegance of solvents. complicated hydrogen bonding is postulated as the foundation motive of their melting point depressions and physicochemical residences; to apprehend these hydrogen-bonded networks, it is imperative to look at these structures as dynamic entities using both simulations and experiments. This review emphasizes the current study’s efforts to elucidate the next steps needed to increase a fundamental framework wished for a deeper understanding of DESs. It covers recent trends in DES studies, frames terrific medical questions, and identifies promising research thrusts aligned with the advancement of the sphere closer to predictive fashions and a fundamental understanding of those solvents

 Keywords: Choline chloride Deep eutectic solvents, Eutectic factor, Herbal deep eutectic solvents, Physicochemical home, Supramolecular community           

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Bhaker, Int. J. Sci. Info. 2023, 1 (2)

Preparation Of Ursolic Acid-loaded Eudragit-e Nanocarrier

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AUTHOR

Rajat Lathwal*

ABSTRACT

Ursolic acid (UA), a triterpenoid could hinder the progression of tumor cells but its potential for clinical utilization is significantly hindered by its poor solubility due to its hydrophobic nature. The present study is aimed to develop Ursolic acid-loaded Eudragit-E nanoparticles (UENPs) using the nanoprecipitation technique. We observed that UENPs possess particle size in the 22 – 39 nm range and an encapsulation efficiency of 60%. Furthermore, Eudragit-E at 8 mg/ml and poloxamer at 0.8% w/w were competent to produce isolated and free-flowing nanoparticles. These findings suggest the utilization of UA-entrapped Eudragit-E nanoparticles as an advanced drug delivery tool to combat cancer.

 Keywords: Anti-cancer activity, Nanoplatforms, Polymeric Particle size, Ursolic acid           

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Lathwal . Int. J. Sci. Info. 2023, 1 (2)

Medicinal and Ayurvedic Aspects of Resourceful Herb: Akarkara

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AUTHOR

Jyoti, M1,  Manan Kumar2 ,Deepika1* , Mukesh R, Jangra3  

ABSTRACT  

Akarkara (Anacyclus pyrethrum) is widely used as a drug in Indian Ayurveda and Unani medicines. It has numerous therapeutic properties and is one of the eleven sacred medicines as described in Ayurveda (Wealth of India). Pellitorine and alkyl amide are the major constituents. This paper reviews medicinal properties, traditional homemade remedies, and side effects of an excessive dose.    

Keywords:   Anacyclus pyrethrum, Anti-bacterial, Ayurvedic proprietary medicine, Pellitorine

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Deepika et al., Int. J. Sci. Info. 2023, 1(1)