Heavy metals and their side effects on human beings

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AUTHOR

Rajat Lathwal*

ABSTRACT  

Ursolic acid (UA), a triterpenoid could hinder the progression of tumor cells but its potential for clinical utilization is significantly hindered by its poor solubility due to its hydrophobic nature. The present study is aimed to develop Ursolic acid-loaded Eudragit-E nanoparticles (UENPs) using the nanoprecipitation technique. We observed that UENPs possess particle size in the 22 – 39 nm range and an encapsulation efficiency of 60%. Furthermore, Eudragit-E at 8 mg/ml and poloxamer at 0.8% w/w were competent to produce isolated and free-flowing nanoparticles. These findings suggest the utilization of UA-entrapped Eudragit-E nanoparticles as an advanced drug delivery tool to combat cancer.

 Keywords: Anti-cancer activity, Nanoplatforms, Polymeric Particle size, Ursolic acid           

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Lathwal . Int. J. Sci. Info. 2023, 1 (2)

In Vitro Flowering in Orchid Species

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AUTHOR

Sanyogita*

ABSTRACT  

Flowering is an evasive and interesting of all plant’s developmental processes. Orchids’ relatively lengthy juvenile phase would be cut short, and a deeper understanding of the physiological, genetic, and molecular aspects of flowering would be gained thanks to plants’ ability to initiate flowering in vitro. All studies that have been done on orchid in vitro flowering that are currently accessible are included in this review.  

Keywords: Dendrobium, orchids, In vitro flowering, Plant growth regulators, Plant tissue culture      

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Sanyogita, Int. J. Sci. Info. 2023, 1 (1)

A Review of the Chemicals Used in Mummification During the Process of Mummification

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AUTHOR

Bhaker Khusboo*

ABSTRACT  

The potential of ancient Egyptians to keep the human body through embalming has no longer only involved people on account of that antiquity, however, additionally has constantly raised the query of how this wonderful chemical substance and ritual system was nearly accomplished. Here we integrate archaeological, philological, and natural residue analysis, dropping new light on the exercise and economic system of embalming in ancient Egypt. This review presents an awareness of the usages of mummification materials which includes Natron salt, Coniferous resin, Mastic, Beeswax, Bitumen, Cassia, onions Lichens, and gums Arabic in historic Egypt to decide their effectiveness in the maintenance of the frame. For every cloth, the chemical method, the history, and the function in the upkeep of the body are offered.it is shown that natron salt turned into the most crucial material to desiccate a corpse and that the vegetable substances referred to above have anti-bacterial houses that included the frame from microbial attack

 Keywords: Beeswax, Bitumen, Lichens, Mummification, Natron salt, Vegetable materials    

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Bhaker Khushboo, Int. J. Sci. Info. 2023, 1 (1)

Origin of HIV-1 Virus and the Global Pandemic AIDS

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AUTHOR

Ujjwal Jangra*

ABSTRACT  

AIDS-Acquired Immuno Deficiency Syndrome is a viral disease that is caused by HIV. Aids was first discovered in 1981 and HIV as a causative agent was discovered in 1983. HIV is a zoonotic disease that was transferred from non-human primates to humans, due to the trade of primates for meat, and keeping them as pets causes cross-species transmission of the Simian Immunodeficiency virus (SIV) in central and west Africa. Multiple transmission of the SIV virus has resulted in the human lineage of HIV. The high mutation rate in HIV viruses has created a global pandemic. In the present review, the origin of HIV and its transmission among several species is discussed.   

Keywords HIV lineage, SIVczp, SIV, Tethering, West of Africa 

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Jangra Ujjwal, Int. J. Sci. Info. 2023, 1 (1)

A review of bioinformatics applications in cancer research

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AUTHOR

Samos*

ABSTRACT  

The study of epigenetic changes, particularly the acetylation, and deacetylation of histones, is becoming a more crucial topic in the fight against cancer. The ultimate objective of cancer research is the organizing and analysis of the ever-growing data as well as the development of novel treatment or diagnostic approaches. The different effective bioinformatics approaches for cancer research are reviewed in this article. The fundamental ideas and tenets of the significant and widely employed bioinformatics methods are introduced. A list of software and databases that are accessible is also given. Finally, obstacles and future directions for the creation and use of diverse methodologies are highlighted. We propose that assessing such technologies could be one of the crucial phases in the future creation of effective cancer therapy options.

 Keywords: Bioinformatics, Cancer Research, Cheminformatics, Epigenetics, Interactome, and SNP            

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Samos. Int. J. Sci. Info. 2023, 1 (1)

Green synthesis and evaluation of the antibacterial activity of Silver nanoparticles from Bambusa affinis leaves

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AUTHORS

Sandeep Ranga*

ABSTRACT   

Silver nanoparticles (ZnNPs) were synthesized by employing Bambusa affinis leaves extract having a particle size of 24.18 nm from TEM. SEM represents the globular shapes of nanoparticles. The color of the AgO / Bambusa affinis extract solution changed from colorless to dark yellowish. Four IR bands are observed at 3235 cm-1, 1874 cm-1, 1334 cm-1, and 456 cm-1, signifying the presence of portentous molecules as a capping agent for Silver nanoparticles. The antimicrobial potency of green synthesized AgNPs was studied against Escherichia coli. As compared to the control which showed a 48% zone of inhibition, the green synthesized nanoparticles significantly increased the zone of inhibition to 61%.  

 Keywords:  Bambusa affinis, Escherichia coli, Nanoparticles, Silver
.

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Sandeep Ranga*. Int. J. Sci. Info. 2023, 1 (1)